Exemestane will suppress estrogen as well as Letrozole, around 85% reduction. The difference is that with exemestane when you stop using it you will experience little if any estrogen rebound since it binds permanently to the aromatase enzyme. Once exemestane binds to the enzyme that particular enzyme will no longer function. This is not dangerous, because your body will create more aromatase enzyme.

Because exemestane is so effective in eliminating estrogen it is also extremely effective at avoiding the negative effects of estrogen when we’re on a cycle. This includes gynocomastia and excess water retention. Limiting the conversion of testosterone to estrogen by eliminating the aromatase enzyme can be beneficial in minimizing estrogen related side effects.

Because it is so effective at removing estrogen exemestane is also useful during post cycle therapy. If you want to keep the gains you made while on cycle you want to minimize the estrogen in your system as well as stimulating the HPTA to begin normal testosterone production. Exemestane not only increases testosterone and lowers estrogen, but it also increases levels of insulin-like growth Factor (IGF). It’s like a 1-2-3 punch for your PCT.

Exemestane is a steroidal AI. This makes it more useful during PCT because it has been known to cause some androgenic side effects like increased aggressiveness and a good hardening effect. Combined with the drying effect you get from an 85% reduction in estrogen it will keep you ripped and shredded while helping you maintain your hard won lean mass.

Another bonus is that exemestane isn’t too harsh on blood lipids (cholesterol), unlike some of the other AI’s like Letrozole.