There are 3 types of estrogen control typically used during post cycle therapy. They are SERM’s
(Selective Estrogen Receptor Modulators), AI’s (Aromatase Inhibitors) and ATD
(1, 4, 6-androstatriene-3, 17-dione). Each works by a different mechanism to decrease estrogen or
estrogen production. In addition to the estrogen control products there are also supplements that
help to increase testosterone production or provide other benefits during post cycle therapy.

SERM’s work by blocking estrogen from acting on the bodies tissues. There are three main SERM’s that
are used during post cycle therapy. These are tamoxifen citrate (Nolvadex), clomiphene citrate
(Clomid) and toremifene citrate. Click on each name in the table below for a more detailed
description.

AI’s lower estrogen by stopping the activity of the aromatase enzyme. Aromatase is responsible for
the conversion of testosterone to estradiol and androstenedione to estrone. There are 6 AI’s listed
below. They are 6-OXO, anastrozole (Arimidex), letrozole (Femara), exemestane (Aromasin), chrysin
and vitamin C. You can find out more about each by clicking on the name in the table below.

ATD is a recent introduction to estrogen control. It is thought to stop estrogen production in a
manner similar to steroidal AI’s such as exemestane. Brand name ATD’s are Rebound XT, Novedex XT,
Ultra H.O.T and Ultra H.O.T.ter.

In addition to estrogen control it is often good to include testosterone boosters in your post cycle
therapy. Many users commonly include the herbs tribulus, fenugreek and maca as part of their PCT
protocol. Another good addition is Activate by Designer Supplements which is used to free up bound
testosterone.

Finally, the addition of products like Lean Extreme or Retain are helpful in reducing cortisol levels.
Cortisol is often elevated after a cycle of anabolics and keeping it in check can help to maintain
your lean mass while minimizing fat storage.

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One benefit of Clomid over Nolvadex is it appears that Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus (an area of the brain) to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in an increase in testosterone production as well.

Clomiphene citrate causes more side effects than Nolvadex. It will cause more acne, mostly because of the higher dosage. The more scary effect is that Clomid changes the eyesight of long term users. And the change is permanent. That alone is enough to scare me away from Clomiphene citrate, especially when Nolvadex is more potent and raises natural testosterone production.